Abstract:
A nanopore is a nanoscale aperture in an otherwise
impervious membrane (solid state or biological) that
functions as the sole fluidic pathway between two
electrolyte reservoirs. The application of a suitable
voltage bias to one of the reservoirs drives the target
analyte through the nanopore predominantly through
electrophoresis, electroosmosis, or diffusion perturbing
the ionic current flow and generating resistive (or
conductive in some instances) pulses stamping analytespecific information. Molecules/particles are probed one
at a time—single molecule sensing—with added benefits
