In-silico investigation on derivatives of (Z)-N-phenyl acetamidoximes as potential inhibitors against Helicobacter pylori

Abstract

Helicobacter pylori is a major cause of gastrointestinal diseases, including gastritis, gastric and duodenal ulceration, gastric carcinoma, and gastric cancer. Urease enzyme secreted by H. pylori, hydrolyses urea, generating ammonia which neutralizes stomach acid and create a suitable pH environment to the bacterium to survive and colonize in the stomach. The structural unit (UreB) of urease contains two nickel ions (Ni2+) at its active site and they are essential for the catalytic effect of urease