In-silico investigation on derivatives of (Z)-N-phenyl acetamidoximes as potential inhibitors against Helicobacter pylori

Dissanayaka, D. M. P. M.; Gunaratna, M. J.

dc.contributor.author	Dissanayaka, D. M. P. M.
dc.contributor.author	Gunaratna, M. J.
dc.date.accessioned	2022-06-26T10:22:46Z
dc.date.available	2022-06-26T10:22:46Z
dc.date.issued	2022-06
dc.identifier.uri	http://ichemcdr.com:8080/xmlui/handle/123456789/184
dc.description	page 48	en_US
dc.description.abstract	Helicobacter pylori is a major cause of gastrointestinal diseases, including gastritis, gastric and duodenal ulceration, gastric carcinoma, and gastric cancer. Urease enzyme secreted by H. pylori, hydrolyses urea, generating ammonia which neutralizes stomach acid and create a suitable pH environment to the bacterium to survive and colonize in the stomach. The structural unit (UreB) of urease contains two nickel ions (Ni2+) at its active site and they are essential for the catalytic effect of urease	en_US
dc.language.iso	en	en_US
dc.publisher	Institute of chemistry Ceylon	en_US
dc.relation.ispartofseries	39;1
dc.subject	Helicobacter pylori	en_US
dc.subject	Urease enzyme	en_US
dc.subject	Derivatives of (Z)-N-phenyl acetamidoxime	en_US
dc.subject	In silico, Urease inhibition	en_US
dc.title	In-silico investigation on derivatives of (Z)-N-phenyl acetamidoximes as potential inhibitors against Helicobacter pylori	en_US
dc.type	Article	en_US